Mycoplasma hyorhinis‐encoded cytidine deaminase efficiently inactivates cytosine‐based anticancer drugs

Mycoplasma hyorhinis‐encoded cytidine deaminase efficiently inactivates cytosine‐based anticancer drugs

Mycoplasmas may colonize tumor tissue in patients. The cytostatic activity of gemcitabine was dramatically decreased inMycoplasma hyorhinis‐infected tumor cell cultures compared with non‐infected tumor cell cultures. This mycoplasma‐driven drug deamination could be prevented by exogenous administrat...

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Bibliographic Details
Main Authors: Johan Vande Voorde, Peter Vervaeke, Sandra Liekens, Jan Balzarini
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:FEBS Open Bio
Subjects:
Mycoplasma
Cytidine deaminase
Cancer
Nucleoside analogue
Purine nucleoside phosphorylase
Gemcitabine
Online Access:https://doi.org/10.1016/j.fob.2015.07.007

Internet

https://doi.org/10.1016/j.fob.2015.07.007

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