The Disordered EZH2 Loop: Atomic Level Characterization by <sup>1</sup>H<sup>N</sup>- and <sup>1</sup>H<sup>α</sup>-Detected NMR Approaches, Interaction with the Long Noncoding HOTAIR RNA

The Disordered EZH2 Loop: Atomic Level Characterization by <sup>1</sup>H<sup>N</sup>- and <sup>1</sup>H<sup>α</sup>-Detected NMR Approaches, Interaction with the Long Noncoding HOTAIR RNA

The 96-residue-long loop of EZH2 is proposed to play a role in the interaction with long non-coding RNAs (lncRNAs) and to contribute to EZH2 recruitment to the chromatin. However, molecular details of RNA recognition have not been described so far. Cellular studies have suggested that phosphorylatio...

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Bibliographic Details
Main Authors: Csenge Lilla Szabó, Beáta Szabó, Fanni Sebák, Wolfgang Bermel, Agnes Tantos, Andrea Bodor
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
EZH2
intrinsically disordered proteins
IDP–RNA interaction
HOTAIR
fuzzy complex
<sup>1</sup>H<sup>α</sup> detected NMR
Online Access:https://www.mdpi.com/1422-0067/23/11/6150

Internet

https://www.mdpi.com/1422-0067/23/11/6150

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