Hypertonicity induces mitochondrial extracellular vesicles (MEVs) that activate TNF-α and β-catenin signaling to promote adipocyte dedifferentiation

Hypertonicity induces mitochondrial extracellular vesicles (MEVs) that activate TNF-α and β-catenin signaling to promote adipocyte dedifferentiation

Abstract Background Recent studies demonstrated that elevated osmolarity could induce adipocyte dedifferentiation, representing an appealing procedure to generate multipotent stem cells. Here we aim to elucidate the molecular mechanisms that underlie osmotic induction of adipocyte reprogramming. Met...

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Bibliographic Details
Main Authors: Guopan Liu, Ying Wang, Yilin Pan, Li Tian, Ming Ho Choi, Li Wang, Jin Young Kim, Jian Zhang, Shuk Han Cheng, Liang Zhang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Stem Cell Research & Therapy
Subjects:
Multipotent stem cells
Adipocyte dedifferentiation
Hypertonic treatment
Mitochondrial EVs
TNF-α
Wnt/β-catenin signaling
Online Access:https://doi.org/10.1186/s13287-023-03558-3

Internet

https://doi.org/10.1186/s13287-023-03558-3

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