Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation

Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation

Abstract Background Oral squamous cell carcinoma (OSCC) is a malignant tumor that may occur anywhere within the oral cavity. The survival rate of OSCC patients has not improved over the past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes. We investigated the r...

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Bibliographic Details
Main Authors: Yuan-Hua Wu, Wun-Syuan Wu, Li-Ching Lin, Chiang-Shin Liu, Sheng-Yow Ho, Bour-Jr Wang, Bu-Miin Huang, Ya-Ling Yeh, Hui-Wen Chiu, Wei-Lei Yang, Ying-Jan Wang
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Oral squamous cell carcinoma
Radiation
TRAF6
Ubiquitination
Autophagy
Online Access:http://link.springer.com/article/10.1186/s13046-018-0760-0

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http://link.springer.com/article/10.1186/s13046-018-0760-0

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