Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis

Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis

Sensorineural hearing loss is the most common long-term deficit after pneumococcal meningitis (PM), occurring in up to 30% of surviving patients. The infection and the following overshooting inflammatory host response damage the vulnerable sensory cells of the inner ear, resulting in loss of hair ce...

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Bibliographic Details
Main Authors: Silvia T. Erni, Gabriella Fernandes, Michelle Buri, Michael Perny, Rolf Jan Rutten, Johannes M. van Noort, Pascal Senn, Denis Grandgirard, Marta Roccio, Stephen L. Leib
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neurology
Subjects:
sensorineural hearing loss
S.pneumoniae
HspB5
inflammation
oto-protection
hair cells
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00570/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.00570/full

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