Non-electrophilic NRF2 activators promote wound healing in human keratinocytes and diabetic mice and demonstrate selective downstream gene targeting

Non-electrophilic NRF2 activators promote wound healing in human keratinocytes and diabetic mice and demonstrate selective downstream gene targeting

Abstract The transcription factor NRF2 plays an important role in many biological processes and is a promising therapeutic target for many disease states. NRF2 is highly expressed in the skin and is known to play a critical role in diabetic wound healing, a serious disease process for which treatmen...

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Bibliographic Details
Main Authors: May Barakat, Chen Han, Lin Chen, Brian P. David, Junhe Shi, Angela Xu, Kornelia J. Skowron, Tatum Johnson, Reginald A. Woods, Aparna Ankireddy, Sekhar P. Reddy, Terry W. Moore, Luisa A. DiPietro
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Nuclear factor erythroid 2 related factor 2
NRF2 activation
Keratinocyte
Oxidative stress
Diabetic wound healing
Online Access:https://doi.org/10.1038/s41598-024-75786-3

Internet

https://doi.org/10.1038/s41598-024-75786-3

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