Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray

Abstract Pain and itch are recognized as antagonistically regulated sensations; pain suppresses itch, whilst pain inhibition enhances itch. The neural mechanisms at the central nervous system (CNS) underlying these pain-itch interactions still need to be explored. Here, we revealed the contrasting r...

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Bibliographic Details
Main Authors: Tatsuroh Kaneko, Asuka Oura, Yoshiki Imai, Ikue Kusumoto-Yoshida, Takuro Kanekura, Hiroyuki Okuno, Tomoyuki Kuwaki, Hideki Kashiwadani
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05997-x