Potential mechanism of Jatropha gossypifolia phenolic derivatives in enhancing insulin-signalling cascades GLUT 4, IRβ and GSK-3β in streptozotocin nicotinamide induced type II diabetic in wistar rat model

Potential mechanism of Jatropha gossypifolia phenolic derivatives in enhancing insulin-signalling cascades GLUT 4, IRβ and GSK-3β in streptozotocin nicotinamide induced type II diabetic in wistar rat model

Objective: Diabetes mellitus is a metabolic syndrome that alters the composition of carbohydrates, proteins and fat content in the body due to decreased insulin secretion. This disrupts the insulin-signaling cascade, resulting in failure in the targeted tissues, such as insulin-stimulated glucose ab...

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Bibliographic Details
Main Authors: Issac Praveen Kumar, P. Snega Priya, Ramu Meenatchi, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Saad Ali S. Aljohani, Rami Adel Pashameah, Abdullah Hamadi, Mansuor A. Alanazi, Jesu Arockiaraj
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of King Saud University: Science
Subjects:
Jatropha gossypifolia
Wistar albino rats
Streptozotocin–nicotinamide induction
Gene and protein expression
Anti-hyperglycemic activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364722004049

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