An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

Abstract Early in the SARS-CoV-2 pandemic concerns were raised regarding infection of new animal hosts and the effect on viral epidemiology. Infection of other animals could be detrimental by causing clinical disease, allowing further mutations, and bares the risk for the establishment of a non-huma...

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Bibliographic Details
Main Authors: Martijn A. Langereis, Irina C. Albulescu, Judith Stammen-Vogelzangs, Morindy Lambregts, Ken Stachura, Suzan Miller, Angela M. Bosco-Lauth, Airn E. Hartwig, Stephanie M. Porter, Michelle Allen, Mark Mogler, Frank J. M. van Kuppeveld, Berend-Jan Bosch, Paul Vermeij, Ad de Groof, Richard A. Bowen, Randy Davis, Zach Xu, Ian Tarpey
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00390-9

Internet

https://doi.org/10.1038/s41541-021-00390-9

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