Differential Effects of Oleic and Palmitic Acids on Lipid Droplet-Mitochondria Interaction in the Hepatic Cell Line HepG2

Differential Effects of Oleic and Palmitic Acids on Lipid Droplet-Mitochondria Interaction in the Hepatic Cell Line HepG2

Fatty acid overload, either of the saturated palmitic acid (PA) or the unsaturated oleic acid (OA), causes triglyceride accumulation into specialized organelles termed lipid droplets (LD). However, only PA overload leads to liver damage mediated by mitochondrial dysfunction. Whether these divergent...

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Bibliographic Details
Main Authors: Andrea Eynaudi, Francisco Díaz-Castro, Juan Carlos Bórquez, Roberto Bravo-Sagua, Valentina Parra, Rodrigo Troncoso
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Nutrition
Subjects:
lipid droplets
mitochondria
fatty acids
hepatocytes
oxygen consumption
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2021.775382/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2021.775382/full

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