Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

Summary: Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly understood. Here, we show that static tension impacts immune cell function, maturation, and metabolism. Bone-marrow-derived and/or splenic...

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Bibliographic Details
Main Authors: Mainak Chakraborty, Kevin Chu, Annie Shrestha, Xavier S. Revelo, Xiangyue Zhang, Matthew J. Gold, Saad Khan, Megan Lee, Camille Huang, Masoud Akbari, Fanta Barrow, Yi Tao Chan, Helena Lei, Nicholas K. Kotoulas, Juan Jovel, Chiara Pastrello, Max Kotlyar, Cynthia Goh, Evangelos Michelakis, Xavier Clemente-Casares, Pamela S. Ohashi, Edgar G. Engleman, Shawn Winer, Igor Jurisica, Sue Tsai, Daniel A. Winer
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
mechanosensing
dendritic cells
immunometabolism
innate immunity
danger signals
tension
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720315989

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http://www.sciencedirect.com/science/article/pii/S2211124720315989

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