Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium–Sensing Receptor

Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium–Sensing Receptor

BackgroundMonocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline‐induced pulmonary artery endothelial injury and pulmonary hypertension remains unknown. The extracellular calcium–sensing receptor (CaSR) and particularl...

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Bibliographic Details
Main Authors: Rui Xiao, Yuan Su, Tian Feng, Mengxiang Sun, Bingxun Liu, Jiwei Zhang, Yankai Lu, Jiansha Li, Tao Wang, Liping Zhu, Qinghua Hu
Format: Article
Language:English
Published: Wiley 2017-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelial injury
extracellular calcium–sensing receptor
intracellular calcium
monocrotaline
pulmonary hypertension
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.004865

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https://www.ahajournals.org/doi/10.1161/JAHA.116.004865

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