Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages

Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages

Murine macrophages activated by the Toll-like receptor 4 agonist lipopolysaccharide (LPS) polarize to the M1 type by inducing proinflammatory marker proteins and changing their energy metabolism to increased aerobic glycolysis and reduced respiration. We here show that the aliphatic isothiocyanate s...

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Bibliographic Details
Main Authors: Sheyda Bahiraii, Martin Brenner, Fangfang Yan, Wolfram Weckwerth, Elke H. Heiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
sulforaphane
macrophages
M1 polarization
glycolysis
PKM2
interleukin 1 beta
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.935692/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.935692/full

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