Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice

Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice

Abstract Background Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination. Recently, two PADs, PAD2 and PAD4, have been linked to hormone signaling in vitro and the goal of this study was to test for links between PAD2/PAD...

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Bibliographic Details
Main Authors: Kelly L. Sams, Chinatsu Mukai, Brooke A. Marks, Chitvan Mittal, Elena Alina Demeter, Sophie Nelissen, Jennifer K. Grenier, Ann E. Tate, Faraz Ahmed, Scott A. Coonrod
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Reproductive Biology and Endocrinology
Subjects:
PAD2
PAD4
Citrullination
Hormone signaling
Estrogen receptor
Androgen receptor
Online Access:https://doi.org/10.1186/s12958-022-01018-w

Internet

https://doi.org/10.1186/s12958-022-01018-w

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