Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

Non-malignant breast epithelial cells cultured in three-dimensional laminin-rich extracellular matrix (lrECM) form well organized, growth-arrested acini, whereas malignant cells form continuously growing disorganized structures. While the mechanical properties of the microenvironment have been shown...

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Bibliographic Details
Main Authors: Benjamin L Ricca, Gautham Venugopalan, Saori Furuta, Kandice Tanner, Walter A Orellana, Clay D Reber, Douglas G Brownfield, Mina J Bissell, Daniel A Fletcher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
breast cancer
breast epithelial cells
malignancy
phenotypic reversion
mechanobiology
Online Access:https://elifesciences.org/articles/26161

Internet

https://elifesciences.org/articles/26161

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