Development, validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of rosuvastatin and metformin in human plasma and its application to a pharmacokinetic study

Development, validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of rosuvastatin and metformin in human plasma and its application to a pharmacokinetic study

A new, simple and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of rosuvastatin (ROS) and metformin (MET) in human plasma was developed. The assay procedure involved simple protein precipitation with acetonitrile. Following precipitation, fr...

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Bibliographic Details
Main Authors: P Pavan Kumar, T. E. G. K. Murthy, M V Basaveswara Rao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Journal of Advanced Pharmaceutical Technology & Research
Subjects:
Liquid chromatography-tandem mass spectrometry
metformin
method validation
pharmacokinetics
rosuvastatin
Online Access:http://www.japtr.org/article.asp?issn=2231-4040;year=2015;volume=6;issue=3;spage=118;epage=124;aulast=Kumar

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http://www.japtr.org/article.asp?issn=2231-4040;year=2015;volume=6;issue=3;spage=118;epage=124;aulast=Kumar

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