Multiple Myeloma-Derived Extracellular Vesicles Impair Normal Hematopoiesis by Acting on Hematopoietic Stem and Progenitor Cells

Multiple Myeloma-Derived Extracellular Vesicles Impair Normal Hematopoiesis by Acting on Hematopoietic Stem and Progenitor Cells

Multiple myeloma (MM) is characterized by the abnormal proliferation of clonal plasma cells (PCs) in bone marrow (BM). MM-PCs progressively occupy and likely alter BM niches where reside hematopoietic stem and progenitor cells (HSPCs) whose viability, self-renewal, proliferation, commitment, and dif...

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Bibliographic Details
Main Authors: Ilaria Laurenzana, Stefania Trino, Daniela Lamorte, Angelo De Stradis, Michele Santodirocco, Alessandro Sgambato, Luciana De Luca, Antonella Caivano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Medicine
Subjects:
multiple myeloma
extracellular vesicles
hematopoiesis
differentiation
hematopoietic stem and progenitor cells
microRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.793040/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.793040/full

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