YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload

YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload

The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the heart against acute blood pressure elevation. The nuclear effector of the Hippo pathway, Yes-associated protein 1 (YAP), is a...

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Bibliographic Details
Main Authors: Toshihide Kashihara, Risa Mukai, Shin-ichi Oka, Peiyong Zhai, Yasuki Nakada, Zhi Yang, Wataru Mizushima, Tsutomu Nakahara, Junco S. Warren, Maha Abdellatif, Junichi Sadoshima
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-03-01
Series:The Journal of Clinical Investigation
Subjects:
Cardiology
Online Access:https://doi.org/10.1172/JCI150595

Internet

https://doi.org/10.1172/JCI150595

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