DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis

DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis

Chronic inflammation is strongly associated with an increased risk of developing colorectal cancer. DNA hypermethylation of CpG islands alters the expression of genes in cancer cells and plays an important role in carcinogenesis. Chronic inflammation is also associated with DNA methylation alteratio...

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Bibliographic Details
Main Authors: Ashley R. Maiuri, Sudha S. Savant, Ram Podicheti, Douglas B. Rusch, Heather M. O’Hagan
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Epigenetics
Subjects:
inflammation
dna methylation
colon cancer
decitabine
interferon signaling
Online Access:http://dx.doi.org/10.1080/15592294.2019.1634986

Internet

http://dx.doi.org/10.1080/15592294.2019.1634986

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