Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications

Abstract Glioma, the most common primary malignant tumor of the central nervous system, lacks effective targeted therapies. This study investigates the role of SOAT1, a key gene involved in cholesterol esterification, in glioma prognosis and its association with ferroptosis. Although the impact of S...

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Bibliographic Details
Main Authors: Shicheng Sun, Guoliang Qi, Hao Chen, Dong He, Dengzhen Ma, Yifan Bie, Linzong Xu, Bin Feng, Qi Pang, Hua Guo, Rui Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06282-1