Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling

Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling

Breast cancer is the most common cancer among women worldwide. Chemotherapy followed by endocrine therapy is the standard treatment strategy after surgery or radiotherapy. However, breast cancer is highly resistant to the treatments leading to the recurrence of breast cancer. As a result, the develo...

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Bibliographic Details
Main Authors: Ruhainee Tohkayomatee, Somrudee Reabroi, Duangjai Tungmunnithum, Warisara Parichatikanond, Darawan Pinthong
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
andrographolide
estrogen receptor (ER)
PI3K/AKT/mTOR pathway
microRNA-21
breast cancer cell lines
Online Access:https://www.mdpi.com/1420-3049/27/11/3544

Internet

https://www.mdpi.com/1420-3049/27/11/3544

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