Bone marrow angiotensin AT receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions

Bone marrow angiotensin AT receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions

Background: Bone marrow (BM) Angiotensin II (Ang II) type 1 (AT 1 ) receptor plays a crucial role in atherosclerosis development; however, the effect of BM Ang II type 2 (AT 2 ) receptor on atherogenesis remains undefined. Methods and results: We generated BM chimera apoE-deficient ( apoE −/− ) mice...

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Bibliographic Details
Main Authors: Taku Kato, Hiroyuki Kawahito, Sou Kishida, Daisuke Irie, Noriyuki Wakana, Masakazu Kikai, Hiroki Takata, Takehiro Ogata, Tomomi Ueyama, Satoaki Matoba, Hiroyuki Yamada
Format: Article
Language:English
Published: SAGE Publications 2015-12-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320314561138

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https://doi.org/10.1177/1470320314561138

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