Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells

Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells

High-linear-energy-transfer (LET) radiation is more lethal than similar doses of low-LET radiation types, probably a result of the condensed energy deposition pattern of high-LET radiation. Here, we compare high-LET α-particle to low-LET X-ray irradiation and monitor double-strand break (DSB) proces...

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Bibliographic Details
Main Authors: Stefan J. Roobol, Irene van den Bent, Wiggert A. van Cappellen, Tsion E. Abraham, Maarten W. Paul, Roland Kanaar, Adriaan B. Houtsmuller, Dik C. van Gent, Jeroen Essers
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
DNA double-strand breaks
high linear energy transfer
alpha particles
homologous recombination
live-cell microscopy
nonhomologous DNA end-joining
Online Access:https://www.mdpi.com/1422-0067/21/18/6602

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https://www.mdpi.com/1422-0067/21/18/6602

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