Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells

Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells

High-linear-energy-transfer (LET) radiation is more lethal than similar doses of low-LET radiation types, probably a result of the condensed energy deposition pattern of high-LET radiation. Here, we compare high-LET α-particle to low-LET X-ray irradiation and monitor double-strand break (DSB) proces...

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Bibliographic Details
Main Authors:	Stefan J. Roobol, Irene van den Bent, Wiggert A. van Cappellen, Tsion E. Abraham, Maarten W. Paul, Roland Kanaar, Adriaan B. Houtsmuller, Dik C. van Gent, Jeroen Essers
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	International Journal of Molecular Sciences
Subjects:	DNA double-strand breaks high linear energy transfer alpha particles homologous recombination live-cell microscopy nonhomologous DNA end-joining
Online Access:	https://www.mdpi.com/1422-0067/21/18/6602

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