Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes

Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes

Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed. Various oils, surfactants, and cosurfactants were screened for their...

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Bibliographic Details
Main Authors: Aristote B. Buya, Romano Terrasi, Jérémie K. Mbinze, Giulio G. Muccioli, Ana Beloqui, Patrick B. Memvanga, Véronique Préat
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
SNEDDSs
bioavailability
quality-by-design
Online Access:https://www.mdpi.com/1999-4923/13/9/1388

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https://www.mdpi.com/1999-4923/13/9/1388

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