Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer’s Disease

Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon is a well-established inhibitor of autophagy in all cells. However, Rubicon pa...

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Bibliographic Details
Main Authors: Sandra Espinoza, Felipe Grunenwald, Wileidy Gomez, Felipe García, Lorena Abarzúa-Catalan, Sebastián Oyarce-Pezoa, Maria Fernanda Hernandez, Bastián I. Cortés, Markus Uhrig, Daniela P. Ponce, Claudia Durán-Aniotz, Claudio Hetz, Carol D. SanMartín, Victor H. Cornejo, Fernando Ezquer, Valentina Parra, Maria Isabel Behrens, Patricio A. Manque, Diego Rojas-Rivera, René L. Vidal, Ute Woehlbier, Melissa Nassif
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
Alzheimer’s disease
autophagy
Rubicon
KIAA0226
RUBCN
APP
Online Access:https://www.mdpi.com/2073-4409/11/12/1860

Internet

https://www.mdpi.com/2073-4409/11/12/1860

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