Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish

Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish

The mammalian Diaphanous-related (mDia) formins are cytoskeletal regulators that assemble and, in some cases, bundle filamentous actin (F-actin), as well as stabilize microtubules. The development of small molecule antagonists and agonists that interrogate mDia formin function has allowed us to inve...

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Bibliographic Details
Main Authors: Hunter LeCorgne, Andrew M. Tudosie, Kari Lavik, Robin Su, Kathryn N. Becker, Sara Moore, Yashna Walia, Alexander Wisner, Daniel Koehler, Arthur S. Alberts, Frederick E. Williams, Kathryn M. Eisenmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
SMIFH2
intramimics
formin
zebrafish
mDia
actin cytoskeleton
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00340/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00340/full

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