N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling

N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling

Abstract Background Glioblastomas multiforme (GBM) is the most devastating primary intracranial malignancy lacking effective clinical treatments. Notch2 has been established to be a prognostic marker and probably involved in GBM malignant progression. N-acetylcysteine (NAC), a precursor of intracell...

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Bibliographic Details
Main Authors: Jie Deng, An-Dong Liu, Guo-Qing Hou, Xi Zhang, Kun Ren, Xuan-Zuo Chen, Shawn S. C. Li, Yao-Song Wu, Xuan Cao
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioblastoma
Notch2
N-acetylcysteine
Buthionine sulfoximine
Lysosome
Itch
Online Access:http://link.springer.com/article/10.1186/s13046-018-1016-8

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http://link.springer.com/article/10.1186/s13046-018-1016-8

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