Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells

Summary: In mouse, although four Argonaute (AGO) proteins with partly overlapping functions in small-RNA pathways exist, only Ago2 deficiency causes embryonic lethality. To investigate the role of AGO2 during mouse early development, we generated Ago2-deficient mouse embryonic stem cells (mESCs) and...

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Bibliographic Details
Main Authors: Richard Patryk Ngondo, Daniel Cirera-Salinas, Jian Yu, Harry Wischnewski, Maxime Bodak, Sandrine Vandormael-Pournin, Anna Geiselmann, Rahel Wettstein, Janina Luitz, Michel Cohen-Tannoudji, Constance Ciaudo
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117305714