RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts

RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts

Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression. Currently, most of our understanding of SNCA regulation is protein-b...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Fedon-Giasin Kattan, Pelagia Koukouraki, Athanasios K. Anagnostopoulos, George T. Tsangaris, Epaminondas Doxakis
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: The Royal Society 2023-11-01
Sraith:Open Biology
Ábhair:
SNCA
AUF1/HNRNPD
post-transcriptional regulation
nucleocytoplasmic shuttling
deadenylation
RNA binding proteins
Rochtain ar líne:https://royalsocietypublishing.org/doi/10.1098/rsob.230158

Ar líne

https://royalsocietypublishing.org/doi/10.1098/rsob.230158

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