IL-24 is the key effector of Th9 cell-mediated tumor immunotherapy

Summary: Th9 cells are powerful effector T cells for cancer immunotherapy. However, the underlying antitumor mechanism of Th9 cells still needs to be further elucidated. Here, we show that Th9 cells express high levels of not only IL-9, but also IL-24. We found that knockout of Il24 gene in Th9 cell...

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Bibliographic Details
Main Authors: Jintong Chen, Yunwei Zhang, Hua Zhang, Mingyue Zhang, He Dong, Tianxue Qin, Sujun Gao, Siqing Wang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223016085