hPMSCs-Derived Exosomal miRNA-21 Protects Against Aging-Related Oxidative Damage of CD4+ T Cells by Targeting the PTEN/PI3K-Nrf2 Axis

Mesenchymal stem cells (MSCs)-derived exosomes were considered a novel therapeutic approach in many aging-related diseases. This study aimed to clarify the protective effects of human placenta MSCs-derived exosomes (hPMSC-Exo) in aging-related CD4+ T cell senescence and identified the underlying mec...

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Main Authors: Yanlian Xiong, Yanlei Xiong, Hengchao Zhang, Yaxuan Zhao, Kaiyue Han, Jiashen Zhang, Dongmei Zhao, Zhenhai Yu, Ziran Geng, Longfei Wang, Yueming Wang, Xiying Luan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.780897/full