Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.

The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes. A number of potent small molecule inhibitors of Kv1.3 channel have been reported, some of which...

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Bibliographic Details
Main Authors: Yunzhao R Ren, Fan Pan, Suhel Parvez, Andrea Fleig, Curtis R Chong, Jing Xu, Yongjun Dang, Jin Zhang, Hongsi Jiang, Reinhold Penner, Jun O Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2602975?pdf=render

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http://europepmc.org/articles/PMC2602975?pdf=render

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