Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies

Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies

Abstract Background An alarming requirement for finding newer antidiabetic glitazones as agonists to PPARγ are on its utmost need from past few years as the side effects associated with the available drug therapy is dreadful. In this context, herein, we have made an attempt to develop some novel gli...

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Bibliographic Details
Main Authors: Subhankar P. Mandal, Aakriti Garg, P. Prabitha, Ashish D. Wadhwani, Laxmi Adhikary, B. R. Prashantha Kumar
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Chemistry Central Journal
Subjects:
PPARγ
Pharmacophore
Molecular docking
Glucose uptake assay
3D-QSAR
CoMSIA
Online Access:http://link.springer.com/article/10.1186/s13065-018-0508-0

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http://link.springer.com/article/10.1186/s13065-018-0508-0

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