HLA-B*27 Heavy Chain Homo-Oligomers Promote the Cytotoxicity of NK Cells via Activation of PI3K/AKT Signaling

HLA-B*27 Heavy Chain Homo-Oligomers Promote the Cytotoxicity of NK Cells via Activation of PI3K/AKT Signaling

<i>Background</i> and <i>Objectives:</i> Ankylosing spondylitis (AS) is a chronic inflammatory disease and is highly linked with the expression of the human leukocytic antigen-B*27 (HLA-B*27) genotype. HLA-B*27 heavy chain (B*27-HC) has an innate characteristic to slowly fold...

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Bibliographic Details
Main Authors: Hui-Chun Yu, Kuang-Yung Huang, Ming-Chi Lu, Hsien-Yu Huang Tseng, Su-Qin Liu, Ning-Sheng Lai, Hsien-Bin Huang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Medicina
Subjects:
ankylosing spondylitis
human leukocytic antigen-B*27
NK cells
KIR3DL2
PI3K/AKT signaling
Online Access:https://www.mdpi.com/1648-9144/58/10/1411

Internet

https://www.mdpi.com/1648-9144/58/10/1411

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