Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis

Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis

Fusion of modified LDL in the arterial wall promotes atherogenesis. Earlier we showed that thermal denaturation mimics LDL remodeling and fusion, and revealed kinetic origin of LDL stability. Here we report the first quantitative analysis of LDL thermal stability. Turbidity data show sigmoidal kinet...

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Bibliographic Details
Main Authors: Mengxiao Lu, Donald L. Gantz, Haya Herscovitz, Olga Gursky
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Journal of Lipid Research
Subjects:
LDL aggregation, fusion, and rupture
sigmoidal denaturation kinetics
LDL subclasses
acidic pH
high-order reaction
lipid-lowering therapies
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520431943

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http://www.sciencedirect.com/science/article/pii/S0022227520431943

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