SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway

SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway

Background: Postoperative cognitive dysfunction (POCD) is a common complication after surgery and anesthesia. In this study, we aimed to determine the neuroprotective mechanism of Sirtuin 3 (SIRT3) and propofol in POCD. Methods: The cognitive dysfunction models in C57BL/6J mice were induced and trea...

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Bibliographic Details
Main Authors: Shang Li, Yi Zhou, Huaying Hu, Xiaodong Wang, Junjun Xu, Chaobo Bai, Junliang Yuan, Dongliang Zhang
Format: Article
Language:English
Published: IMR Press 2022-11-01
Series:Frontiers in Bioscience-Landmark
Subjects:
postoperative cognitive dysfunction
sirt3
propofol
autophagy
Online Access:https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711303

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https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711303

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