SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway
Background: Postoperative cognitive dysfunction (POCD) is a common complication after surgery and anesthesia. In this study, we aimed to determine the neuroprotective mechanism of Sirtuin 3 (SIRT3) and propofol in POCD. Methods: The cognitive dysfunction models in C57BL/6J mice were induced and trea...
Main Authors: | Shang Li, Yi Zhou, Huaying Hu, Xiaodong Wang, Junjun Xu, Chaobo Bai, Junliang Yuan, Dongliang Zhang |
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Format: | Article |
Language: | English |
Published: |
IMR Press
2022-11-01
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Series: | Frontiers in Bioscience-Landmark |
Subjects: | |
Online Access: | https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711303 |
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