Basal ganglia lesions after MPTP administration in rhesus monkeys

Basal ganglia lesions after MPTP administration in rhesus monkeys

In monkeys, intracarotid infusion of a single low dose of MPTP reliably induces a hemiparkinsonian syndrome that is stable over time. This model has been widely used to assess novel anti-parkinsonian therapies. Here, we report the exceptional finding of severe necrotic lesions that were observed in...

Full description

Bibliographic Details
Main Authors: M.E. Emborg, J. Moirano, K.T. Schafernak, M. Moirano, M. Evans, T. Konecny, B. Roitberg, P. Ambarish, E. Mangubat, Y. Ma, D. Eidelberg, J. Holden, J.H. Kordower, J.E. Leestma
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Neurobiology of Disease
Subjects:
MPTP
Nonhuman primates
Globus pallidus
Striatum
Necrosis
Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000581

Internet

http://www.sciencedirect.com/science/article/pii/S0969996106000581

Similar Items