Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR)

Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR)

High rates of cell proliferation and protein synthesis in pancreatic cancer are among many factors leading to endoplasmic reticulum (ER) stress. To restore cellular homeostasis, the unfolded protein response (UPR) activates as an adaptive mechanism through either the IRE1<inline-formula><ma...

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Bibliographic Details
Main Authors: Gehan Botrus, Richard M. Miller, Pedro Luiz Serrano Uson Junior, Geoffrey Kannan, Haiyong Han, Daniel D. Von Hoff
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
unfolded protein response (UPR)
endoplasmic reticulum (ER) stress
pancreatic cancer
apoptosis
Online Access:https://www.mdpi.com/1422-0067/24/1/577

Internet

https://www.mdpi.com/1422-0067/24/1/577

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