Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization
The observation that tissues that undergo more stem cell divisions are less prone to develop cancer presents a paradox as these tissues should have more opportunity to accumulate cancer-causing mutations. Here, the authors present a solution to the paradox by showing how hierarchical tissues can mai...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29004-1 |