The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

Abstract Background To evaluate the cross-talk between BRCA1-IRIS (IRIS)-overexpressing (IRISOE) TNBC cells and tumor-resident mesenchymal stem cells (MSCs) that triggers the aggressiveness or elimination of IRISOE TNBC tumors. Methods We analyzed the effect of silencing or inactivating IRIS on the...

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Bibliographic Details
Main Authors: Daniel Ryan, Bibbin T. Paul, Jim Koziol, Wael M. ElShamy
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Breast Cancer Research
Subjects:
BRCA1-IRIS
Triple-negative breast cancer
Metastasis
Mesenchymal stem cells
IL-6
Prostaglandin E2
Online Access:http://link.springer.com/article/10.1186/s13058-019-1131-2

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http://link.springer.com/article/10.1186/s13058-019-1131-2

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