Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Only a subset of patients with triple-negative breast cancer (TNBC) benefits from a combination of radio- (RT) and immunotherapy. Therefore, we aimed to examine the impact of radioresistance and brain metastasizing potential on the immunological phenotype of TNBC cells following hypofractionated RT...

Full description

Bibliographic Details
Main Authors: Simon Gehre, Felix Meyer, Azzaya Sengedorj, Fridolin Grottker, Clara M. Reichardt, Jannik Alomo, Kerstin Borgmann, Benjamin Frey, Rainer Fietkau, Michael Rückert, Udo S. Gaipl
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
radiotherapy
breast cancer
radioresistance
immune checkpoint molecules
dendritic cells
tumor cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.981239/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.981239/full

Similar Items