Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Only a subset of patients with triple-negative breast cancer (TNBC) benefits from a combination of radio- (RT) and immunotherapy. Therefore, we aimed to examine the impact of radioresistance and brain metastasizing potential on the immunological phenotype of TNBC cells following hypofractionated RT...

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Bibliographic Details
Main Authors: Simon Gehre, Felix Meyer, Azzaya Sengedorj, Fridolin Grottker, Clara M. Reichardt, Jannik Alomo, Kerstin Borgmann, Benjamin Frey, Rainer Fietkau, Michael Rückert, Udo S. Gaipl
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
radiotherapy
breast cancer
radioresistance
immune checkpoint molecules
dendritic cells
tumor cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.981239/full

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