Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Abstract Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute to therapeutic resistance. Thus, targeting RNA splicing to redirect isoform expression of apoptosis-related genes could lead to promising ant...

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Bibliographic Details
Main Authors: Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, Xiaohua Chen, Boyi Yu, Xiaogang Zhen, Jing Si, Chao Sun, Hong Zhang, Cuixia Di
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06507-x

Internet

https://doi.org/10.1038/s41419-024-06507-x

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