Impact of age‐related T‐cell dynamics on the identification of biomarkers predictive of immunotherapy discontinuation: A prospective cohort study

Impact of age‐related T‐cell dynamics on the identification of biomarkers predictive of immunotherapy discontinuation: A prospective cohort study

Abstract Background The impact of biologic aging on immune checkpoint inhibitor (ICI) toxicity and efficacy is underexplored in metastatic melanoma (MM). In peripheral blood T lymphocytes (PBTLs), biologic aging is characterized by changes in T‐cell composition and cellular senescence. Whether indic...

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Bibliographic Details
Main Authors: Jason E. Galloway, Andrea M. Holderbaum, Namrata Arya, Suohui Zhang, Michael S. Bodnar, Ruthann Norman, William E. Carson, Lianbo Yu, Kari L. Kendra, Christin E. Burd
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Aging and Cancer
Subjects:
aging biomarker
CD27
checkpoint inhibitor
melanoma
senescence
Online Access:https://doi.org/10.1002/aac2.12012

Internet

https://doi.org/10.1002/aac2.12012

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