Hormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work

Hormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work

Abstract Elevated cortisol in chronic stress and mood disorders causes morbidity including metabolic and cardiovascular diseases. There is therefore interest in developing drugs that lower cortisol by targeting its endocrine pathway, the hypothalamic–pituitary–adrenal (HPA) axis. However, several pr...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs: Tomer Milo, Shiraz Nir Halber, Moriya Raz, Dor Danan, Avi Mayo, Uri Alon
Formaat: Artikel
Taal:English
Gepubliceerd in: Springer Nature 2025-01-01
Reeks:Molecular Systems Biology
Onderwerpen:
Dynamic Compensation
HPA Axis
Mood Disorders
Systems Endocrinology
Systems Pharmacology
Online toegang:https://doi.org/10.1038/s44320-024-00083-0

Internet

https://doi.org/10.1038/s44320-024-00083-0

Gelijkaardige items