Identification of a Transcription Factor That Regulates Host Cell Exit and Virulence of Mycobacterium tuberculosis.

The interaction of Mycobacterium tuberculosis (Mtb) with host cell death signaling pathways is characterized by an initial anti-apoptotic phase followed by a pro-necrotic phase to allow for host cell exit of the bacteria. The bacterial modulators regulating necrosis induction are poorly understood....

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Bibliographic Details
Main Authors: Lalitha Srinivasan, Serdar A Gurses, Benjamin E Hurley, Jessica L Miller, Petros C Karakousis, Volker Briken
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4871555?pdf=render