Highly Efficient Synthesis of 3,3-Disubstituted Oxindoles through Direct Oxidative Alkylarylation of N-Arylacrylamides with Simple Alkanes

Highly Efficient Synthesis of 3,3-Disubstituted Oxindoles through Direct Oxidative Alkylarylation of N-Arylacrylamides with Simple Alkanes

A direct oxidative alkylarylation reaction of N-arylacrylamides with simple alkanes for the synthesis of 3,3-disubstituted oxindoles under metal-free conditions was demonstrated. By using PhI(OAc)2 [(diacetoxy)iodobenzene] as an oxidant, a series of 3,3-disubstituted oxindoles bearing different aryl...

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Bibliographic Details
Main Authors: Yan Chen, Weihong Song, Zhixiang Zhou, Ziye Zhang, Kai Liu, Xiaofei Zeng, Xiaoyu Han
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2023-05-01
Series:SynOpen
Subjects:
oxindoles
alkylarylation
n-arylacrylamide
phi(oac)2
metal-free
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1751451

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1751451

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