PGRMC2 influences the onset of postmenopausal osteoporosis through disulfidptosis in monocytes: Evidence from experimental validation and Mendelian randomization

PGRMC2 influences the onset of postmenopausal osteoporosis through disulfidptosis in monocytes: Evidence from experimental validation and Mendelian randomization

This study explores the role of disulfidptosis in monocytes and its relation to postmenopausal osteoporosis (PMOP). Using single-cell RNA sequencing and microarray assays, we identified key genes: LONRF1, ACAP2, IPO9, and PGRMC2. Through differential analysis, Weighted Gene Co-expression Network Ana...

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Bibliographic Details
Main Authors: Yaobin Wang, Hefang Xiao, Yi Chen, Xiaoyun Sheng, Zhiwei Feng, Bo Peng, Zhongcheng Liu, Hongwei Zhan, Dejian Xiang, Chengjun Zhang, Yayi Xia, Bin Geng
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Heliyon
Subjects:
Disulfidptosis
PMOP
scRNA-seq
Microarray-based assay
Monocytes
Mendelian randomization
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024126011

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http://www.sciencedirect.com/science/article/pii/S2405844024126011

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